Discussion of firstname.lastname@example.org's comment: The author finds a contradiction because the expected reversal potential of Na^+^ (according to the Nernst Eq.) differs from the observed reversal potential of mechanotransduction. However, he failed to take into account the opposite gradient in K^+^, which usually has a high concentration inside hair cells. This is also why neuronal receptors that are nonselective cation channels reverse around zero mV (e.g., AMPA receptors). When multiple ions are involved, one should use the Goldman-Hodgkin-Katz voltage equation, which takes into account the concentration of all ions and their relative permeability through the channel. The experiment of putting 248 mM Na^+^ in the external may be difficult because the total osmolarity of the solution would greatly exceed physiological osmolarity (and that inside the cell). However, one could double the intracellular Na^+^ (preferably by replacing K^+^). The GHK equation predicts the reversal potential to not change greatly as the reversal potential is not very sensitive to the exact gradients of each ion when they have strong opposing gradients (each of the individual ions conducts in a rectifying fashion, inward current is dominated by the ion that is in excess outside, and vice versa, the exact zero crossings of each ion don't matter much in the summed flux).